Linear Attribution Example

Linear Attribution Example

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Transient receptor potential vanilloid type 1 TRPV1 , a nonselective cation channel, is a well-known pain-related receptor. TRPV1 involvement in morphine-induced antinociception, tolerance, and withdrawal symptoms has been previously reported. Emerging evidence indicates that TRPV1 may be related to both the cellular and behavioral effects of addictive drugs. In the present study, we investigated the role of TRPV1 in morphine reward using the conditioned place preference CPP paradigm in mice. Brain TRPV1 may serve as a novel therapeutic target to treat morphine-addictive disorders. The opiate drug morphine has a long history of use both for medical and recreational purposes.

Dermatology

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Real-time Smartphone-based Sleep Staging using 1-Channel EEG Abstract: Automatic and real-time sleep scoring is necessary to develop user interfaces that trigger stimuli in specific sleep stages. However, most automatic sleep scoring systems have been focused on offline data analysis.

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Either your web browser doesn’t support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Cell Cycle Georgetown, Tex. Free to read. We asked whether the anti-inflammatory role of TRPV1 changes with age. In contrast to aseptic SIRS, polymicrobial sepsis induced by cecal ligation and puncture caused accelerated mortality in aged TRPV1-deficient mice as compared with wild-type littermates.

The recovery of TRPV1-deficient mice from hypothermia associated with the cecal ligation and puncture procedure was delayed. Hence, the reversal of the anti-inflammatory role of TRPV1 found in the aged and their decreased systemic inflammatory response are coupled with suppressed defense against microbial infection.

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